Category Archives: pancreatic cancer

Drug Target Identification: And then a miracle occurs

At the front end of most drug discovery programs lies a step called Target Identification, and a few months ago I sat down with a colleague to discuss their approach to target identification.  In particular, “how do you characterize a target”? … Continue reading

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Merrimack’s New Pancreatic Cancer Drug

The intertubes have been abuzz lately with the news of Merrimack’s results from their Phase III trial of a new triplet therapy for pancreatic cancer.  The triplet combines older standard of care drugs like 5FU and leucovorin with their new … Continue reading

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Promising Preclinical Results in Pancreatic Cancer

A recent announcement at the AACRs-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19–23, points to some promising results in recent trials that targeted multiple pathways downstream of KRAS (including PI3K/AKT, RAF/MEK/ERK and RAL).  The studies conducted … Continue reading

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Cui Bono? Finding Super Responders In Clinical Trials

I’m a voracious reader of mysteries in my spare time.  And some juncture in every story, as the detective finds himself staring at the corpse, they ask the inevitable question “Cui Bono — who benefits?”  Oddly enough, this is a … Continue reading

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Abraxane Approved For Treatment of Pancreatic Cancer

The FDA recently approved Abraxane for the treatment of metastatic pancreatic cancer. This is a breakthrough for Celgene (who acquired the drug with their acquisition of Abraxis), and is the first significant change in the treatment of pancreatic cancer in … Continue reading

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ClinVar – A database of mutations and their clinical relevance

One of the key pieces of the drug discovery puzzle involves determining the clinical relevance of the target.  Over the past few years big pharma have been pulling back from this critical part of the drug discovery process and ceding … Continue reading

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Latest Pancreatic Cancer Articles

During the recent ASCO GI conference, the big news was the release of the results of the Abraxane trials.  The data show that the lives of pancreatic cancer patients can be extended by two months when adding Abraxane into the … Continue reading

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