Category Archives: Cancer Research

Drug Target Identification: And then a miracle occurs

At the front end of most drug discovery programs lies a step called Target Identification, and a few months ago I sat down with a colleague to discuss their approach to target identification.  In particular, “how do you characterize a target”? … Continue reading

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Network of BioThings Hackathon #2

This weekend’s Network of BioThings hackathon (#hackNoB) was a great success with some really innovative projects making great strides in a short amount of time. The event was hosted by the Jeff Grethe of the Neuroscience Information Framework group at … Continue reading

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Network of BioThings: Making PDFs Useful

Recently, Andrew Su of Scripps posted a series of blog entries on the Network of Biothings (NoB) efforts, especially their efforts to uncover use cases that could aid medical research. In a nutshell,”The Network of BioThings aims to structure the … Continue reading

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Tinkering With Semantic Markup

One of the key challenges for bioinformaticians in this age is extracting meaningful findings from abstracts and full text articles. Text mining solutions can only take it so far, and previous comparative studies have shown that Amazon Mechanical Turk solutions and … Continue reading

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Assessing Credibility in Scientific Research

Over the past few years, pharmaceutical companies have come to increasingly rely external research to help fill their pipelines.  This greater reliance on academic research is not without it’s risks — chief amongst these is the lack of reproducibility. Amgen … Continue reading

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Promising Preclinical Results in Pancreatic Cancer

A recent announcement at the AACRs-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19–23, points to some promising results in recent trials that targeted multiple pathways downstream of KRAS (including PI3K/AKT, RAF/MEK/ERK and RAL).  The studies conducted … Continue reading

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Cui Bono? Finding Super Responders In Clinical Trials

I’m a voracious reader of mysteries in my spare time.  And some juncture in every story, as the detective finds himself staring at the corpse, they ask the inevitable question “Cui Bono — who benefits?”  Oddly enough, this is a … Continue reading

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