Category Archives: Drug Development

Notes from San Diego KNIME User Group Meeting

This week Brock Luty of Dart Neuroscience hosted the first San Diego KNIME User Group meeting.  Michael Berthold, one of the founders of KNIME, came down from San Francisco to deliver a briefing Mark Donnelly of XIFIN demonstrated how a … Continue reading

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Promising Preclinical Results in Pancreatic Cancer

A recent announcement at the AACRs-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19–23, points to some promising results in recent trials that targeted multiple pathways downstream of KRAS (including PI3K/AKT, RAF/MEK/ERK and RAL).  The studies conducted … Continue reading

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Cui Bono? Finding Super Responders In Clinical Trials

I’m a voracious reader of mysteries in my spare time.  And some juncture in every story, as the detective finds himself staring at the corpse, they ask the inevitable question “Cui Bono — who benefits?”  Oddly enough, this is a … Continue reading

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ClinVar – A database of mutations and their clinical relevance

One of the key pieces of the drug discovery puzzle involves determining the clinical relevance of the target.  Over the past few years big pharma have been pulling back from this critical part of the drug discovery process and ceding … Continue reading

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Latest Pancreatic Cancer Articles

During the recent ASCO GI conference, the big news was the release of the results of the Abraxane trials.  The data show that the lives of pancreatic cancer patients can be extended by two months when adding Abraxane into the … Continue reading

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Latest Pancreatic Cancer News & Articles

News In this weeks news: ABRAXANE Demonstrates Statistically Significant Improvement in Overall Survival for Patients with Advanced Pancreatic Cancer in Phase III Study – Yahoo! Finance MONTPELLIER, France: Skuldtech and AB Science Announce the Identification of New Predictive Markers for … Continue reading

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Pancreatic Cancer News & Articles

News In this weeks news: “Pancreas In A Dish” Will Show How Pancreatic Cancer Forms A tiny, living 3-D organ model of pancreatic ducts has been created by researchers in Toronto to help them understand pancreatic cancer, which is one … Continue reading

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Pancreatic Cancer News and Journal Articles

News In this weeks news: AACR: New Treatments Studied for Pancreatic Cancer –Doctors Lounge Targeting the hedgehog signaling pathway with a smoothened antagonist, GDC-0449, in combination with gemcitabine achieves partial response in some metastatic pancreatic cancer patients; and targeted depletion … Continue reading

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Pancreatic Cancer News From AACR

This week’s collection of news and journal articles include a number of announcements made at the recent AACR meeting in Chicago. News In this weeks news: Whole genome sequencing not informative for all, Johns Hopkins study shows | e! Science … Continue reading

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Latest Pancreatic Cancer News & Journal Articles

The week American Association of Cancer Research (AACR) kicks off its annual meeting in Chicago, and we’ll be bringing you the latest announcements. News In this weeks news: Health News – Metformin May Improve Pancreatic Cancer Prognosis in Patients With … Continue reading

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