Category Archives: Drug Development

Tinkering With Semantic Markup

One of the key challenges for bioinformaticians in this age is extracting meaningful findings from abstracts and full text articles. Text mining solutions can only take it so far, and previous comparative studies have shown that Amazon Mechanical Turk solutions and … Continue reading

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KNIME and Cheminformatics: A Peek Behind The Curtain

Part of what makes user group meetings so interesting is getting the opportunity to peek behind the curtains and see someone else’s operation.  In last night’s, KNIME user group meeting, Brock Luty of Dart NeuroScience gave an interesting perspective on … Continue reading

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SwissModel: It’s not what you think

One of the things that I’m always curious about, is the effect of a sequence variation on the conformation of a target.  Recently I wrote about ClinVar and SwissVar, two tools for examining variants and their associations with disease.  Since … Continue reading

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Merrimack’s New Pancreatic Cancer Drug

The intertubes have been abuzz lately with the news of Merrimack’s results from their Phase III trial of a new triplet therapy for pancreatic cancer.  The triplet combines older standard of care drugs like 5FU and leucovorin with their new … Continue reading

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Notes from San Diego KNIME User Group Meeting

This week Brock Luty of Dart Neuroscience hosted the first San Diego KNIME User Group meeting.  Michael Berthold, one of the founders of KNIME, came down from San Francisco to deliver a briefing Mark Donnelly of XIFIN demonstrated how a … Continue reading

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Promising Preclinical Results in Pancreatic Cancer

A recent announcement at the AACRs-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19–23, points to some promising results in recent trials that targeted multiple pathways downstream of KRAS (including PI3K/AKT, RAF/MEK/ERK and RAL).  The studies conducted … Continue reading

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Cui Bono? Finding Super Responders In Clinical Trials

I’m a voracious reader of mysteries in my spare time.  And some juncture in every story, as the detective finds himself staring at the corpse, they ask the inevitable question “Cui Bono — who benefits?”  Oddly enough, this is a … Continue reading

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